Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report

Authors

  • Rajkumar Chauhan RSO, Medical Physicist, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  • Pranav Chadha Head of the Unit, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  • Kaustav Talapatra Head of the Department, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  • Reuben Jake Rodrigues Medical Officer, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai.
  • Amrita Shrivastava DMRT, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
  • Mayuresh D. Virkar Clinical Associates, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  • Sameer Tulpule Consultant, Haematology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
  • Santanu Sen Consultant, Haematology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India

DOI:

https://doi.org/10.31878/ijcbr.2020.64.06

Keywords:

Hematopoietic Stem Cell Transplantation; Graft-versus-Host Disease; Thalassemia Minor;, Radiotherapy; Myeloablative conditioning; Haemoglobinopathies

Abstract

Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.

Downloads

Published

2020-10-29

How to Cite

Chauhan, R., Chadha, P., Talapatra, K., Rodrigues, R. J., Shrivastava, A., Virkar, M. D., Tulpule, S., & Sen, S. (2020). Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report. International Journal of Clinical and Biomedical Research, 6(4), 25–28. https://doi.org/10.31878/ijcbr.2020.64.06

Issue

Section

Case Reports